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Effects of graded carbohydrate supplementation on the immune response in cycling.

TitelEffects of graded carbohydrate supplementation on the immune response in cycling.
MedientypJournal Article
Year of Publication2006
AutorenScharhag J, Meyer T, Auracher M, Gabriel HH, Kindermann W
JournalMed Sci Sports Exerc
Volume38
Ausgabe2
Seitennummerierung286-92
Date Published2006 Feb
ISSN0195-9131
SchlüsselwörterAdult, Analysis of Variance, Bicycling, C-Reactive Protein, Humans, Hydrocortisone, Interleukin-6, Leukocytes, Lymphocyte Count, Male, Oxygen Consumption, Polysaccharides
Zusammenfassung

PURPOSE: This study examined the acute immune response after three standardized cycling sessions of 4-h duration in the field with varying carbohydrate (CHO) supplementation in a randomized, double-blind, placebo-controlled fashion. We hypothesized that the ingestion of carbohydrate (6 or 12% CHO beverages; placebo (P) without CHO) during exercise attenuates the exercise-induced immune response in a dose-dependent manner.

METHODS: A total of 14 male competitive cyclists and triathletes (age: 25 +/- 5 yr; height: 180 +/- 7 cm; weight: 72 +/- 9 kg; VO2max: 67 +/- 6 mL.min(-1).kg(-1)) cycled for 4 h on a 400-m track at a given workload of 70% of the individual anaerobic threshold (198 +/- 21 W). Leukocyte and lymphocyte subpopulations were measured by flow cytometry before, immediately, and 1 and 19 h after exercise. In addition, C-reactive protein (CRP) interleukin 6 (IL-6), and cortisol were determined.

RESULTS: The exercise-induced increase in leukocytes, neutrophils, and monocytes was significantly attenuated to the same extent by 6 and 12% CHO (P < 0.001). No differences could be demonstrated for lymphocytes and natural killer cells. The increase in CRP was attenuated significantly by 12% CHO only (P < 0.05), whereas the increase in cortisol and IL-6 was significantly reduced by 6 and 12% CHO (P < 0.001). The postexercise neutrophilia, which dominated the exercise-induced leukocytosis, was strongly related to the postexercise concentration of cortisol (r = 0.72; P < 0.001).

CONCLUSIONS: Because of the lacking dose-dependent difference, the ingestion of at least 6% CHO beverages can sufficiently attenuate the exercise-induced immune response and stress, especially in phagocytizing cells (neutrophils and monocytes) by the reduced release of cortisol.

DOI10.1249/01.mss.0000191437.69493.d4
Alternate JournalMed Sci Sports Exerc
PubMed ID16531897
Nicht definiert