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Hippocampal plasticity in response to exercise in schizophrenia.

TitelHippocampal plasticity in response to exercise in schizophrenia.
MedientypJournal Article
Year of Publication2010
AutorenPajonk F-G, Wobrock T, Gruber O, Scherk H, Berner D, Kaizl I, Kierer A, Müller S, Oest M, Meyer T, Backens M, Schneider-Axmann T, Thornton AE, Honer WG, Falkai P
JournalArch Gen Psychiatry
Volume67
Problem2
Seitennummerierung133-43
Date Published2010 Feb
ISSN1538-3636
SchlüsselwörterAdult, Aspartic Acid, Chronic Disease, Cognition Disorders, Exercise, Hippocampus, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Neuronal Plasticity, Neuropsychological Tests, Schizophrenia
Zusammenfassung

CONTEXT: Hippocampal volume is lower than expected in patients with schizophrenia; however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to hippocampal plasticity.

OBJECTIVE: To determine whether hippocampal volume would increase with exercise in humans and whether this effect would be related to improved aerobic fitness.

DESIGN: Randomized controlled study.

SETTING: Patients attending a day hospital program or an outpatient clinic.

PATIENTS OR OTHER PARTICIPANTS: Male patients with chronic schizophrenia and matched healthy subjects.

INTERVENTIONS: Aerobic exercise training (cycling) and playing table football (control group) for a period of 3 months.

MAIN OUTCOME MEASURES: Magnetic resonance imaging of the hippocampus. Secondary outcome measures were magnetic resonance spectroscopy, neuropsychological (Rey Auditory Verbal Learning Test, Corsi block-tapping test), and clinical (Positive and Negative Syndrome Scale) features.

RESULTS: Following exercise training, relative hippocampal volume increased significantly in patients (12%) and healthy subjects (16%), with no change in the nonexercise group of patients (-1%). Changes in hippocampal volume in the exercise group were correlated with improvements in aerobic fitness measured by change in maximum oxygen consumption (r = 0.71; P = .003). In the schizophrenia exercise group (but not the controls), change in hippocampal volume was associated with a 35% increase in the N-acetylaspartate to creatine ratio in the hippocampus. Finally, improvement in test scores for short-term memory in the combined exercise and nonexercise schizophrenia group was correlated with change in hippocampal volume (r = 0.51; P < .05).

CONCLUSION: These results indicate that in both healthy subjects and patients with schizophrenia hippocampal volume is plastic in response to aerobic exercise.

DOI10.1001/archgenpsychiatry.2009.193
Alternate JournalArch. Gen. Psychiatry
PubMed ID20124113
Nicht definiert