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Does prolonged cycling of moderate intensity affect immune cell function?

TitelDoes prolonged cycling of moderate intensity affect immune cell function?
MedientypJournal Article
Year of Publication2005
AutorenScharhag J, Meyer T, Gabriel HHW, Schlick B, Faude O, Kindermann W
JournalBr J Sports Med
Volume39
Ausgabe3
Seitennummerierung171-7; discussion 171-7
Date Published2005 Mar
ISSN1473-0480
SchlüsselwörterAcute-Phase Reaction, Adult, Anaerobic Threshold, Bicycling, C-Reactive Protein, Disease Susceptibility, Exercise Test, Humans, Infection, Interleukin-6, Killer Cells, Natural, Male, Monocytes, Neutrophils
Zusammenfassung

BACKGROUND: Prolonged exercise may induce temporary immunosuppression with a presumed increased susceptibility for infection. However, there are only few data on immune cell function after prolonged cycling at moderate intensities typical for road cycling training sessions.

METHODS: The present study examined the influence on immune cell function of 4 h of cycling at a constant intensity of 70% of the individual anaerobic threshold. Interleukin-6 (IL-6) and C-reactive protein (CRP), leukocyte and lymphocyte populations, activities of natural killer (NK), neutrophils, and monocytes were examined before and after exercise, and also on a control day without exercise.

RESULTS: Cycling for 4 h induced a moderate acute phase response with increases in IL-6 from 1.0 (SD 0.5) before to 9.6 (5.6) pg/ml 1 h after exercise and CRP from 0.5 (SD 0.4) before to 1.8 (1.3) mg/l 1 day after exercise. Although absolute numbers of circulating NK cells, monocytes, and neutrophils increased during exercise, on a per cell basis NK cell activity, neutrophil and monocyte phagocytosis, and monocyte oxidative burst did not significantly change after exercise. However, a minor effect over time for neutrophil oxidative burst was noted, tending to decrease after exercise.

CONCLUSIONS: Prolonged cycling at moderate intensities does not seem to seriously alter the function of cells of the first line of defence. Therefore, the influence of a single typical road cycling training session on the immune system is only moderate and appears to be safe from an immunological point of view.

DOI10.1136/bjsm.2004.013060
Alternate JournalBr J Sports Med
PubMed ID15728699
PubMed Central IDPMC1725141
Nicht definiert