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Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners

TitelDecreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners
MedientypJournal Article
Year of Publication1999
AutorenBroocks A, Meyer T, George A, Hillmer-Vogel U, Meyer D, Bandelow B, Hajak G, Bartmann U, Gleiter CH, Rüther E
JournalNeuropsychopharmacology
Volume20
Ausgabe2
Seitennummerierung150-61
Date Published1999 Feb
ISSN0893-133X
SchlüsselwörterAdult, Anxiety, Behavior, Body Temperature, Double-Blind Method, Exercise Test, Female, Hormones, Humans, Male, Neurosecretory Systems, Physical Endurance, Piperazines, Pyrimidines, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, Receptors, Serotonin, 5-HT1, Running
Zusammenfassung

Several clinical studies suggest antidepressive and anxiolytic effects of regular aerobic exercise. To study the effects of exercise on central serotonergic receptor sensitivity, we performed neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-CPP, 0.4 mg/kg), ipsapirone (0.3 mg/kg) and placebo in 12 marathon runners and 12 healthy controls not practicing regular exercise. After administration of the nonselective serotonergic agonist m-CPP, which exerts a number of well-reproducible effects mainly by means of its action on 5-HT2C receptors, marathon runners showed a significantly reduced cortisol response in comparison to the control group. There was also a statistical trend toward a blunted prolactin response after m-CPP in the athlete group. In contrast, the increase of cortisol and the hypothermia observed after administration of the 5-HT1A agonist ipsapirone were of the same magnitude in both groups. The behavioral response to m-CPP or ipsapirone and the mean maximal increases of plasma adrenaline and noradrenaline did not differ between the marathon and the control group. In conclusion, exercise-induced downregulation of 5-HT2C receptors could play an important role in mediating the anxiolytic and antidepressive effects of exercise.

DOI10.1016/S0893-133X(98)00056-6
Alternate JournalNeuropsychopharmacology
PubMed ID9885795
Nicht definiert